• Ceftazidime-avibactam to treat life-threatening infections by carbapenem-resistant pathogens in critically ill mechanically ventilated patients 

      Tsolaki V., Mantzarlis K., Mpakalis A., Malli E., Tsimpoukas F., Tsirogianni A., Papagiannitsis C., Zygoulis P., Papadonta M.-E., Petinaki E., Makris D., Zakynthinos E. (2020)
      Data on the effectiveness of ceftazidime-avibactam (CAZ-AVI) in critically ill, mechanically ventilated patients are limited. The present retrospective observational cohort study, which was conducted in two general intensive ...
    • Early bacterial identification among intubated patients with COVID-19 or influenza pneumonia: A european multicenter comparative clinical trial 

      Rouzé A., Martin-Loeches I., Povoa P., Metzelard M., Cheyron D.D., Lambiotte F., Tamion F., Labruyere M., Geronimi C.B., Nieszkowska A., Nyunga M., Pouly O., Thille A.W., Megarbane B., Saade A., Diaz E., Magira E., Llitjos J.-F., Cilloniz C., Ioannidou I., Pierre A., Reignier J., Garot D., Kreitmann L., Baudel J.-L., Fartoukh M., Plantefeve G., Beurton A., Asfar P., Boyer A., Mekontso-Dessap A., Makris D., Vinsonneau C., Floch P.-E., Weiss N., Ceccato A., Artigas A., Bouchereau M., Duhamel A., Labreuche J., Nseir S., Poissy J., Favory R., Preau S., Jourdain M., Boyd S., Coelho L., Maizel J., Cuchet P., Zarrougui W., Boyer D., Quenot J.-P., Imouloudene M., Luyt C.-E., van der Linden T., Bardin J., Voicu S., Azoulay E., Goma G., Pene F., Torres A., Thevenin D., Ehrmann S., Argaud L., Guidet B., Voiriot G., Contou D., Le Marec J., Demiselle J., Meguerditchian D., Razazi K., Tsolaki V., Sejourne C., Brunin G., LeGuennec L., Morales L., the coVAPid Study Group (2021)
      Rationale: Early empirical antimicrobial treatment is frequently prescribed to critically ill patients with coronavirus disease (COVID-19) based on Surviving Sepsis Campaign guidelines. Objectives: We aimed to determine ...
    • Early gastrostomy reduces the rate of ventilator-associated pneumonia in stroke or head injury patients 

      Kostadima, E.; Kaditis, A. G.; Alexopoulos, E. I.; Zakynthinos, E.; Sfyras, D. (2005)
      Presence of a nasogastric tube is a risk factor for the development of ventilator-associated pneumonia (VAP). Alternatively, gastrostomy can be used for administration of enteral feedings. To determine whether early ...
    • Intra-Abdominal Hypertension is a Risk Factor for Increased VAP Incidence: A Prospective Cohort Study in the ICU of a Tertiary Hospital 

      Papakrivou E., Makris D., Manoulakas E., Karvouniaris M., Zakynthinos E. (2020)
      Background: Ventilator-associated pneumonia (VAP) might be increased in cases with intra-abdominal hypertension (IAH). However, despite animal experimentation and physiological studies on humans in favor of this hypothesis, ...
    • Molecular characteristics and predictors of mortality among Gram-positive bacteria isolated from bloodstream infections in critically ill patients during a 5-year period (2012–2016) 

      Papadimitriou-Olivgeris M., Kolonitsiou F., Karamouzos V., Tsilipounidaki K., Nikolopoulou A., Fligou F., Marangos M., Petinaki E., Spiliopoulou I. (2020)
      To identify the molecular characteristics of Gram-positive cocci isolated from blood cultures and clinical outcome among critically ill patients. This retrospective study was conducted in the general intensive care unit ...
    • Pre-intensive care unit intubation and subsequent delayed intensive care unit admission is independently associated with increased occurrence of ventilator-associated pneumonia 

      Tsakiridou E., Mega A.-M., Zakynthinos E., Melissopoulou T., Stamos G., Argyriou K., Pangrati S., Deliolanis I., Floros I. (2018)
      Introduction: Critically ill intubated patients are at risk for ventilator-associated pneumonia. However, intubation may not occur in intensive care unit (ICU) and subsequent ICU admission may be delayed. Objectives: To ...
    • Rapid dissemination of colistin and carbapenem resistant Acinetobacter baumannii in Central Greece: Mechanisms of resistance, molecular identification and epidemiological data 

      Oikonomou O., Sarrou S., Papagiannitsis C.C., Georgiadou S., Mantzarlis K., Zakynthinos E., Dalekos G.N., Petinaki E. (2015)
      Background: Colistin-resistant/carbapenem-resistant Acinetobacter baumannii is a significant challenge for antibiotic treatment and infection control policies. Since 2012, in Central Greece an increase of colistin/pan- ...
    • Relationship between corticosteroid use and incidence of ventilator-associated pneumonia in COVID-19 patients: a retrospective multicenter study 

      Saura O., Rouzé A., Martin-Loeches I., Povoa P., Kreitmann L., Torres A., Metzelard M., Du Cheyron D., Lambiotte F., Tamion F., Labruyere M., Boulle Geronimi C., Luyt C.-E., Nyunga M., Pouly O., Thille A.W., Megarbane B., Saade A., Magira E., Llitjos J.-F., Ioannidou I., Pierre A., Reignier J., Garot D., Baudel J.-L., Voiriot G., Plantefeve G., Morawiec E., Asfar P., Boyer A., Mekontso-Dessap A., Bardaka F., Diaz E., Vinsonneau C., Floch P.-E., Weiss N., Ceccato A., Artigas A., Nora D., Duhamel A., Labreuche J., Nseir S., Bouchereau M., Boyd S., Coelho L., Maizel J., Cuchet P., Zarrougui W., Boyer D., Quenot J.-P., Imouloudene M., Pineton de Chambrun M., Van der Linden T., Arrive F., Voicu S., Azoulay E., Moglia E., Pene F., Cilloniz C., Thevenin D., Larrat C., Argaud L., Guidet B., Contou D., Beurton A., Meguerditchian D., Razazi K., Tsolaki V., Marzouk M., Brunin G., Marois C., Morales L., coVAPid Study Group (2022)
      Background: Ventilator-associated pneumonia (VAP) is common in patients with severe SARS-CoV-2 pneumonia. The aim of this ancillary analysis of the coVAPid multicenter observational retrospective study is to assess the ...
    • Relationship between SARS-CoV-2 infection and the incidence of ventilator-associated lower respiratory tract infections: a European multicenter cohort study 

      Rouzé A., Martin-Loeches I., Povoa P., Makris D., Artigas A., Bouchereau M., Lambiotte F., Metzelard M., Cuchet P., Boulle Geronimi C., Labruyere M., Tamion F., Nyunga M., Luyt C.-E., Labreuche J., Pouly O., Bardin J., Saade A., Asfar P., Baudel J.-L., Beurton A., Garot D., Ioannidou I., Kreitmann L., Llitjos J.-F., Magira E., Mégarbane B., Meguerditchian D., Moglia E., Mekontso-Dessap A., Reignier J., Turpin M., Pierre A., Plantefeve G., Vinsonneau C., Floch P.-E., Weiss N., Ceccato A., Torres A., Duhamel A., Nseir S., Favory R., Preau S., Jourdain M., Poissy J., Bouras C., Saint Leger P., Fodil H., Aptel F., Van Der Linden T., Thille A.W., Azoulay E., Pène F., Razazi K., Bagate F., Contou D., Voiriot G., Thevenin D., Guidet B., Le Guennec L., Kouatchet A., Ehrmann S., Brunin G., Morawiec E., Boyer A., Argaud L., Voicu S., Nieszkowska A., Kowalski B., Goma G., Diaz E., Morales L., Tsolaki V., Gtavriilidis G., Mentzelopoulos S.D., Nora D., Boyd S., Coelho L., Maizel J., Du Cheyron D., Imouloudene M., Quenot J.-P., Guilbert A., Cilloniz C., on behalf of the coVAPid study Group (2021)
      Purpose: Although patients with SARS-CoV-2 infection have several risk factors for ventilator-associated lower respiratory tract infections (VA-LRTI), the reported incidence of hospital-acquired infections is low. We aimed ...
    • Relationship between ventilator-associated pneumonia and mortality in COVID-19 patients: a planned ancillary analysis of the coVAPid cohort 

      Nseir S., Martin-Loeches I., Povoa P., Metzelard M., Du Cheyron D., Lambiotte F., Tamion F., Labruyere M., Makris D., Boulle Geronimi C., Pinetonde Chambrun M., Nyunga M., Pouly O., Mégarbane B., Saade A., Gomà G., Magira E., Llitjos J.-F., Torres A., Ioannidou I., Pierre A., Coelho L., Reignier J., Garot D., Kreitmann L., Baudel J.-L., Voiriot G., Contou D., Beurton A., Asfar P., Boyer A., Thille A.W., Mekontso-Dessap A., Tsolaki V., Vinsonneau C., Floch P.-E., Le Guennec L., Ceccato A., Artigas A., Bouchereau M., Labreuche J., Duhamel A., Rouzé A., Favory R., Préau S., Jourdain M., Poissy J., Leger P.S., Van der Linden T., Veinstein A., Azoulay E., Pene F., Martin M., Razazi K., Plantefeve G., Fartoukh M., Thevenin D., Guidet B., Weiss N., Kouatchet A., Salmon C., Brunin G., Nemlaghi S., Meguerditchian D., Argaud L., Voicu S., Luyt C.-E., Kowalski B., Moglia E., Morales L., Koutsoukou A., Mentzelopoulos S.D., Nora D., Boyd S., Maizel J., Cuchet P., Delforge Q., Quenot J.-P., Boyer D., Cilloniz C., the coVAPid study group (2021)
      Background: Patients with SARS-CoV-2 infection are at higher risk for ventilator-associated pneumonia (VAP). No study has evaluated the relationship between VAP and mortality in this population, or compared this relationship ...
    • Secondary bacterial infections are a leading factor triggering New Onset Atrial Fibrillation in intubated ICU Covid-19 ARDS patients 

      Zakynthinos G.E., Tsolaki V., Karavidas N., Vazgiourakis V., Dimeas G., Mantzarlis K., Vavougios G., Makris D. (2022)
      Background: Cardiac arrhythmias, mainly atrial fibrillation (AF), is frequently reported in COVID-19 patients, more often in Intensive Care Unit (ICU) patients, yet causality has not been virtually explored. Moreover, ...
    • Ten ineffective interventions to prevent ventilator-associated pneumonia 

      Makris D., Luna C., Nseir S. (2018)
      [No abstract available]
    • Toll-like receptor 2, 4 and 9 polymorphisms and their association with ICU-acquired infections in Central Greece 

      Chatzi M., Papanikolaou J., Makris D., Papathanasiou I., Tsezou A., Karvouniaris M., Zakynthinos E. (2018)
      Purpose: To test the potential of four common Toll-like receptor (TLR) polymorphisms to predispose to specific intensive care unit (ICU)-acquired infections and affect outcomes in a Greek ICU. Materials and methods: The ...